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This is a basic IGF-1 cycle guide
Author: Mr Sparkle
What is it? And why is the difference between huIGF-1 and LR3 IGF-1?
IGF-1 stands for insulin like growth factor. IGF-I is the primary protein
involved in responses of cells to growth hormone (GH): that is, IGF-1 is
produced in response to GH and then induces cellular activities. One such
example is muscle growth or hyperplasia
This compound also makes the human body more sensitive to insulin. It is the
most potent growth factor found in the human body. IGF-1 causes muscle cell
hyperplasia, which is an actual splitting and forming of new muscle cells,
this is a good thing.
LR3 IGF-1
Long Recumbent 3 IGF-1, which is an 83 amino acid analog of human IGF-1
sequence with the substitution of an arg for the glu at position 3 (hence R3),
and a 13 amino acid extension peptide at the N-terminus (hence the long).
HuIGF-1
It has a 70 amino acid string. It is very short lived in the body (half life
of probably around 10-15 minutes). This type of IGF-1 is very useful if you
are seeking local site growth. Since it is so short lived, little of the IGF-1
makes it to other tissues and IGF-1 receptors in the body. The way to inject
this is immediately post work out into the muscle that you wish to have local
site growth.
This coupled with PGF2a and TNE would do wonders for site specific growth IMO.
Usage
It needs to be shot PWO. Most shoot bilaterally into the muscle that was
worked.
Stacking- because LR3 increases hyperplasia it is best when used in
conjunction of other AAS.
The ideal situation would be to inject twice ED due to the life of LR3. If
this isnt feasible PWO will suffice, and suffice well.
If you are on your off day, in the AM is best. It will help fight catabolism.
If you add insulin to your LR3, be careful. LR3 will make you more sensitive
to the effects that insulin has on you. So raise your PWO carb intake to
accommodate the added LR3.
If you have never ran insulin before, DO NOT add it with LR3.
What can I expect?
First off you can expect to drop a little BF if your diet is good. LR3 seems
to burn off fat.
You can expect an increase in hunger, this is awesome when bulking. That
though can be controlled while cutting.
Another thing to remember is hyperplaisa, once again the forming of new muscle
cells, thus more size. Strength will go up along with the new muscle mass.
You can expect great pumps. For some people so bad it hurts... you be the
judge. I for one have never got pumps that hurt like that... for me personally
I feel more pumps with insulin.
Dosing For LR3
The general consensus for dosing LR3 seems to be 40mcg to 60mcg. For no longer
than 5 weeks. Do not exceed 100mcg. The average user should have no reason to
ever come close to that dose. Some people shoot everyday, some just PWO. So on
the days you do not work out the best thing to do is shoot whenever you wake
up this helps maintain constant blood levels and helps fight of catabolism.
The first time user should just use 40mcg on PWO days only. This way you can
use 40mcg for 5 weeks assuming you have just one MG of LR3. It is a great
starting dose that will get you results. But if you have used 40mcg in the
past and didnt see the results you wanted, try 60mcg.
A great way to run a cycle that includes IGF would be this-
weeks 1-12 test enanthate E3D 500-750mg a week
Weeks 1-4, 15-19* 40mcg of LR3 ED
PCT 14-18
*IMO I do not feel that its needed the first week of PCT, if my weight falls
off it does in weeks 2-3, so I want to aleviate that problem.
Dosing For huIGF
This is about the same as LR3, this is stritcly my opinion based on what I
have gatherd and read. As there is next to no information on this. So from
what I know about it, this is how Id/do/will use it.
PWO with 30-40mcg into each muscle that was worked. 20-30 min later, repeat.
Do this for 4 times. for a total of 120-160mcg
And if I were using this Id use it with humalog. The insulin will remain
active for over and hour after the IGF was injected. So this will get all the
possible gains from it that you could.
How to figure out dosing
Ok I get, I should use 40mcg.... but how do I figure that out?
1mg = 1000mcg... assuming there is 1ml of liquid we can say that 1ml = 1000mcg
and also = 100units...
So 2 units = 20 mcg
The best way to measure this is to use an insulin syringe. You can get away
with a 1cc syringe but I prefer to use the .5cc or even the .33cc ones. They
measure out each unit, so when you are measuring two units it is much easier
on the smaller pin. While the 1cc syringe is fine, it is mesured out by two IU
at a time. So one "tick" on the 1cc is 2iu, the .5cc each
"tick" is one IU.
Wow so you mean you???re telling me I shoot 4iu of this stuff? What if I do
not get it all out of there ?
I thought you would never ask. I have found the best way to get it and even
measure my LR3 is like this. First draw out 30iu of B12 or BW (bacteriostatic
water) on the dot. Then draw your LR3 out for a total of 34iu. This means you
have 4iu of LR3 in the end of your syringe. Shoot out all of it and that way
you can be sure all of the LR3 is out and into your desired muscle of choice.
Reconstitution.
RedBaron has a great thread on reconstitution with AA (acetic acid), check it
out here.
But just about always you do not have to worry about reconstituting it
yourself. All of the manufacturers usually suspend their LR3 in either BA or
AA for you.
Storage, Taken from MR
The stability of a liquid solution of LR3IGF-I was monitored for a period of
two years at storage conditions of -20 C, +4 C, +22 C, and +37 C. The final
concentration of LR3IGF-I was in acetic acid. At various time points, samples
were taken and compared to a lyophilized control (stored at 4 C). Listed below
are the stability results for each respective storage condition.
Storage Condition: -20 C (-4 F)
Biological Potency No Change up to 2 years
Immunological Activity No Change up to 2 years
Mobility of Protein No Change up to 2 years
Elution Profile by reversed phased HPLC No Change up to 2 years
Storage Condition: +4 C (39.2 F)
Biological Potency No Change up to 2 years
Immunological Activity No Change up to 2 years
Mobility of Protein No Change up to 2 years
Elution Profile by reversed phased HPLC No Change up to 2 years
Storage Condition: +22 C (71.6 F)
Biological Potency No Change up to 2 years
Immunological Activity No Change up to 2 years
Mobility of Protein No Change up to 2 years
Elution Profile by reversed phased HPLC No Change up to 2 years
Storage Condition: +37 C (98.6 F)
Biological Potency No Change up to 1 year
Immunological Activity No Change up to 1 year
Mobility of Protein No Change up to 1 year
Elution Profile by reversed phased HPLC No Change up to 1 year
In conclusion
There is no significant difference in the potency of LR3IGF-I associated with
the storage of the liquid formulation when stored at this range of
temperatures. There is no evidence for loss of biological activity at any of
the tested temperatures when stored as a liquid product. As you can see IGF
can be quite stable for even a year at room temp, but if you want to keep it
around for a while stick it into the fridge. So IMO the best way to store LR3
that is suspended in BA is in the freezer. The BA wont allow it to freeze. And
if you have it suspended in AA, store it in the fridge.
Feel free to discuss this article at worldclassbodybuilding.com
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