Glucophase XR!
In
order to fully understand what makes Glucophase XR such a great supplement, we
need to give a brief history about its ingredients and their uses. We will also
help to educate you about similar products that are currently available
The
main ingredient in Glucophase XR is K-R-Ala. It is a form of Alpha-Lipoic Acid
(ALA), which has been called the "ideal antioxidant". It is one of the most
potent, free radical scavengers known to man. It protects cell membranes by
boosting and recycling inactive antioxidants into active antioxidants. This
activation boosts the free radical fighting action of popular antioxidants like
vitamin C, vitamin E, and NAC. Alpha-lipoic acid is known to reverse Syndrome X
or Insulin Resistance Syndrome. It does this by improving insulin response and
sensitivity, which also helps you burn fat, build lean muscle, and keep blood
sugar levels even. This is very important in low-carb/ketogenic diets. The R
form of ALA has been shown to increase ATP production which results in strength
gains in human muscle tissue and an increase in energy. It also has been shown
to raise serum glutathione levels in blood plasma by over 100%. Glutathione is a
super antioxidant that kills cancer causing toxins such as MTBE and cyandine and
helps to reduce inflammation. Raising glutathione levels fights inflammation
caused by cancer, HIV, and polycystic ovary syndrome by reducing the cytokine
production that causes abnormal cell death and wasting. (1)
WHAT ARE THE PROBLEMS
WITH ALA / R-ALA?
ALA
is made up of two enantiomers, S and R. The S part is of no use to us because it
has been found to inhibit ATP production in muscle tissue. The R part gives us
all of the beneficial effects, including increasing ATP production, lowering
oxidative stress, improving metabolic activity and cellular metabolism.
Unfortunately, the R form is extremely sensitive and becomes unstable when there
are even the smallest changes in light, air, moisture, and temperature. These
changes cause it to decay and polymerize into a sticky, rubbery, or glue like
substance which is useless in the human body within hours of ingestion. R-ALA is
so unstable that is needs to be shipped in dry ice and stored in a cool and dry
place at all times. This instability renders the R-ALA orally inactive. Another
problem associated with R-ALA is that it is a waxy material that has a tendency
to trap high amounts of residual toxic chemicals and waste from manufacturing,
including the carcinogenic solvents dichloromethane, ethylene dichloride, MTBE,
acetonitrile, cyclohexane, toluene, methanol and ethyl acetate.
HOW
DID WE SOLVE THESE PROBLEMS?
Glucophase
XR uses K-R-ALA. Adding Potassium (K) to the R-ALA keeps it stable even in the
most extreme temperatures. Stabilizing it keeps it from decaying and
polymerizing into a useless substance. Due to rigorous testing and the
refinement of R-ALA processing techniques, Designer Supplements can guarantee
that Glucophase XR will be free of toxic solvent residues.
WHY
IS GLUCOPHASE XR SO MUCH BETTER?
Glucophase
XR contains K-R-ALA (the most orally effective form of R-ALA), D-Biotin(Vitamin
H), Quercetin and its analogs Q3D and Q4D.
The
K-R-ALA makes Glucophase XR a powerful insulin mimetic which can reduce carb
related obesity or insulin resistance in muscle cells. It has also been shown to
increase activity in dead human beta cells (cells that produce insulin), improve
insulin sensitivity and increases fatty acid oxidation (fat loss). Insulin is
the most anabolic hormone in the human body, but it has its drawbacks. If your
body doesn?t have enough insulin it can cause muscle wasting however, an
abundance of insulin causes fat gain, especially in problem areas like the lower
stomach, love handles, hips and butt.
We
have added Quercetin and its analogs Q3D and Q4D which have been shown to
increase the body?s use of carbohydrates by shuttling them into the muscle
tissue and preventing the excess from reaching fat cells. (2)
D-Biotin
or Vitamin H has been shown to increase cAMP which in turn causes fatty acid
oxidation and an increase in energy. D-Biotin also activates human insulin
peptide 3, which plays a major role in the development of new muscle tissue. (3)
It also helps to enhance ATP synthesis. (4)
D-Biotin is the most
effective and
therefore most expensive analog of Biotin. (Ten times more expensive.)
Glucophase
XR is the first in a series of new Post Ban Era (PBE) products that Designer
Supplements is developing to be used by men and women, not only to burn fat and
build lean muscle, but to improve overall health.
1.
Human pharmacokinetics of ALA chaper 22 Packer et al.. basel hong kong 1997
pp337-360
dose-proportionality
of oral thioctic acid coincidence of assessment via pooled plasma individual
data, briethaupt-grogler k niebch g et al.. eur j pharm sci 1999 apr 8 (1) 57-65
2. Cermak
r landgraf s, wolffram s "quercetin glucosides inhibit glucose uptake into
brush boarder membrane vesicles of porcine jejunum," BR J nutr 2004
jun;91(6):849-55
3. fu p, layfield
et al "Synthesis, conformation, receptor binding and biological activities
of monbiotinylated human insulin-like peptide-3," j pept res. 2004
feb;63(2):91-8
4.
Sone H, Sasaki et al "biotin
enhances ATP synthesis in panceatic islets of the rat, resulting in
reinforcement of glucose-induced insulin secreation," Biochem Biophys Res
commun 2004 feb 2004 13;314(3):824-9
for any R&D questions about
this product cont
Glucophase XR (GXR)
Dosing
For
gaining lean muscle:
Take 1-2 caps in the a.m. with a decent amount (60-80) of simple carbs and
around 50-75gms of protein. This will cause an insulin spike from the carbs that
normally would only be able to get a small amount of the protein into the
muscle; the rest would go into the fat. However, being more sensitive to insulin
(from the k-r-ala) and having the muscle tissue primed for the aminos and
glucose (from the Q3D, Q4D and d-biotin) you'll shuttle the nutrients into
muscle cells instead. Basically you are using GXR as you would use insulin. Now
post workout, I would take 2-3 caps with a min. 60gms of simple crabs along with
75gms whey protein, this will cause even more to go into the muscle tissue
because you have already primed the environment from working out, you're just
going to make the system work to YOUR advantage for once, instead of having
everything go into some muscle stores and the rest in fat. That is all I would
use for gaining mass, unless you are an extremely lean person/true hard gainer,
I may use 1 cap with each meal just to get the extra protein in the muscles. But
I don't think most will need that much.
Now for fat loss:
You
should be following some type of a lowered carb diet, you would want to use it
for the exact opposite as gaining mass, you would
want to clear sugar from the blood so that the body will use fat stores for
energy. So before bed takes 1 cap, which will lower blood sugar while you sleep,
then when you get up in the am you takes 1 cap, 30 min before doing aerobics,
you should be in a quasi-state of ketosis, which will cause some serious fat
burning. Then after aerobics eat your normal diet throughout the day, if you
have a meal that is higher in carbs take 1 cap 30min. before you eat to keep her
blood sugar levels stable and low (the key to fat loss). Then when you workout,
if you do weight training, I would take 1 cap, 10 min before working out, this
way by the time you are halfway through your workout, you should have some
slight fat burning as well as a better pump even though you are on lowered carbs.
Have your post workout shake, just use simple carbs with protein, 20-30gms of
carbs is just enough to get you through the rest of the night. This will keep
your blood sugar low and stable throughout the day, providing you with specific
times of ketosis for fat burning.
The main difference between the two different ways of cycling is that with
bulking you will be adding more carbs to your meals, now that you can make full
use of ATP stores and for fat loss you will be depleting carbs. If you were
going to do a full Atkins diet you would take 2 caps, every 4-5 hours, for a max
of 8 caps during one day so you can get into ketosis much faster. Then the only
other time I would use GXR while in ketosis is if I was eating something with
Net Carbs, like a Subway wrap.
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