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Cyclofenil
Pharmaceutical Name: Cyclofenil
Drug Class: Selective Estrogen Receptor Modulator
Active Life: 3-5 days
Cyclofenil is a selective estrogen receptor modulator. It works via the same
mechanisms as clomiphene citrate and tamoxifen citrate (1, 2). In acting as an
estrogen receptor anatagonist/agonist, medically it is prescribed to stimulate
ovulation in women and can be used to help raise natural testosterone levels
in men (3). In terms of use for strength athletes, bodybuilders and other
steroid users, like clomiphene citrate and tamoxifen citrate, cyclofenil has
two primary uses.
The first such use would be for the prevention of estrogen-related
gynecomastia. Cyclofenil has the ability to bind to the estrogen receptors in
breast tissue, therefore preventing the formation of gynecomastia. However it
should be noted that cyclofenil appears to be less potent then tamoxifen
citrate in achieving this effect, and therefore users may not want to rely on
it if other options are available.
The second use that cyclofenil may be employed for is post-cycle therapy. In
addition to targeting the estrogen receptors in breast tissue, the compound
also has the ability to bind to the estrogen receptors in the hypothalamus. By
doing so, cyclofenil is able to block the negative feedback inhibition that is
caused by estrogen (3). This creates an environment where there is an increase
in the production of gonadotropin releasing hormone. This in turn signals the
pituitary to raise the amount of luteinizing hormone circulating in the body,
with luteinizing hormone of course being the primary indicator for the testes
to increase the rate of testosterone production. All of this would obviously
be of benefit when a steroid user discontinues his use of anabolic steroids.
By being able to increase the natural testosterone production of a user as
quickly as possible, it is more likely that they will be able to maintain more
of the muscle mass gained during a cycle as well as achieving a more natural
hormonal balance in a shorter period of time.
It should be noted that due to the similar mechanisms by which they work (2),
users that are administering tamoxifen citrate and/or clomiphene citrate are
unlikely to see any increased benefits to adding cyclofenil for either the
purpose of gynecomastia prevention and/or during post-cycle therapy. As long
as the clomiphene citrate/tamoxifen citrate is being taken in adequate
dosages, there is no reason to include cyclofenil.
Use/Dosing for Cyclofenil >
As stated above, similar to tamoxifen citrate and clomiphene citrate,
cyclofenil is primarily used during the post-cycle therapy of a male steroid
user's cycle. This is due to the ability of the compound to inhibit the
negative feedback loop activated via estrogen. This in turn helps to increase
the production of gonadotropin releasing hormone, thereby stimulating the
pituitary to release a larger volume of luteinizing hormone. All of this
brings about a signal for the testes to increase their production of
testosterone.
For the most part, users have anecdotally reported that dosing in the range of
400 to 600mgs per day should be sufficient to provide the effect sought after
by users. The duration of the use of cyclofenil is similar to clomiphene
citrate, usually lasting for approximately four to five weeks for post-cycle
therapy.
As for use as a preventive measure for gynecomastia, it can be run throughout
the cycle of a user for this effect as well. The dosage required varies from
user to user, however it should be relatively lower then those needed for
post-cycle therapy. A dose of between 200-400 milligrams per day should be
sufficient in most cases.
Some users also advocate tapering the dose of cyclofenil during the last few
weeks of administration. However this is more a practice that is based upon
theory rather than solid medical evidence of its productivity.
Risks/Side Effects of using Cyclofenil
There are no real direct negative side effects associated with the use of
cycolfenil. For the most part, any negative side effects that a user may
experience would almost undoubtedly be related to the shift in hormonal
balance that the user is undergoing. Acne, a strained emotional state, oily
skin and a change in sex drive are all symptoms that users may experience once
they cease the administration of anabolics steroids and begin recovering their
natural testosterone production.
Other than these concerns, there is little in the way that short-term or
long-term use of cycolfenil could cause damage to in the human body (4). It is
seemingly safe in terms of possible effects to the body???s hormonal production.
For the vast majority of users the compound is relatively side effect free and
well tolerated.
References
1. Schmidt-Elmendorff H, Kammerling R. [Comparative clinical
studies on clomiphen, cyclofenil and epimestrol (author's transl)]
Geburtshilfe Frauenheilkd. 1977 Jun;37(6):531-41
2. Schopman W, Slager E, Hackeng WH, Mulder H. Stimulation of calcitonin
secretory capacity by increased serum levels of testosterone in men treated
with tamoxifen. Int J Androl. 1987 Dec;10(6):747-51
3. Cox LW. Stimulation of ovulation and spermatogenesis by drugs and hormones.
Mod Med Asia. 1977 Nov;13(11):23-5
4. Herbai G, Ljunghall S. Lipid-lowering effects of two synthetic oestrogen
derivatives with weak genital oestrogen properties. Ups J Med Sci.
1985;90(1):67-72
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