Deca-Durabolin Nandrolone Decanoate
Formula of Base: C18 H26 O2
Formula of Ester: C10 H20 O2
Molecular Weight of Base: 274.4022
Molecular Weight of Ester: 172.2668
Anabolic/Androgenic Ratio: 125/37
Active Life: 14-16 days
Nandrolone is by far one of the most popular anabolic steroids available. This
is due to the compound's affinity for being highly anabolic but relatively
mild in terms of androgenic side effects. Nandrolone is the base steroid
19Nor-testosterone, meaning that it is like testosterone in appearance except
for the absence of a carbon atom in the 19th position. This small change makes
a major difference in the characteristics of the compound (1). Notably, this
change makes nandrolone a less potent agonist of the androgen receptor. This
of course reduces the chance that a user will experience androgenic side
effects. Instead of forming dihydrotestosterone when encountering the 5 alpha
reductase enzyme like testosterone does, nandrolone will form dihydronandrolone. Dihydronandrolone is extremely mild in terms of it's
antagonizing the androgen receptor. Therefore androgenic side effects should
be far less likely to occur with nandrolone than with testosterone.
It is of note however that nandrolone is believed to have some activity as a
progestin in the body. Although progesterone is a c-19 steroid, removal of
this group as in 19-norprogesterone creates a hormone with greater binding
affinity for its corresponding receptor. The compound will stimulate the
progesterone receptor, along with progesterone. Side effects associated with
this activity are similar to some of those related to estrogenic ones
including water retention, acne, and gynecomastia among others. However these
side effects are fairly rare in comparison to more androgenic compounds.
Now, with the reduced chance of negative side effects associated with the use
of nandrolone one would assume that the gains in lean body mass that a user
could expect to make would also be reduced. This is not true however.
Nandrolone is 2.4 times as anabolic as testosterone when compared gram for
gram (1). This does not mean that a user will gain 2.4 times as much muscle if
using nandrolone instead of testosterone however. It is not that easy. It does
show how powerful this drug is and how it can help a user make serious gains
in muscle mass.
Use/Dosing of Deca-Durabolin Nandrolone Decanoate
Due to the active life of the compound, users would only need to administer
nandrolone decanoate once per week to maintain fairly stable of the drug.
However, since the vast majority of users will stack nandrolone with
testosterone (for reasons that will be discussed later in the Side
Effects/Risks section of this profile) and the most commonly used esters need
to be injected more frequently most will simply injected it when it is
convenient, such as twice a week with their testosterone enanthate or
cypionate.
Anecdotally most users report that the full benefits of nandrolone decanoate
will not be felt until the fifth, sixth or even seventh week of using the
compound. This necessitates that users run the drug for at least eleven or
twelve weeks for a cycle of the compound to have the results that a user
expects. Of course, since nandrolone decanoate is a relatively mild drug many
users have run it for extremely lengthy cycles with little in the way of
serious side effects.
Most inexperienced male users will start using about 400mgs of nandrolone
decanoate during their first cycles of the compound. Like most drugs users
have used quite large doses of the compound, with diminishing returns being
seen as these doses go higher and higher.
Females also have found that nandrolone can be quite effective while offering
relatively mild side effects. Doses ranging from about 50 to 150mgs per week
seem to be the norm for most first time users of the compound, again with
these doses increasing as users try to achieve more and more with the
compound.
Side Effects/Risks of using Deca-Durabolin Nandrolone Decanoate
Estrogenic effects are not a major concern with use of nandrolone due to it's
low rate of aromatization. However it can cause progesterone-like effects in
some users. Commonly reported sides effects associated with nandrolone are
such things as acne/oily skin, insomnia, diarrhea, and nausea. These of course
are coupled with the common side effects most often associated with anabolic
steroids including testicular atrophy, gynecomastia (including lactation in
some cases), and sexual dysfunction.
To combat sexual dysfunction most users will stack testosterone with
nandrolone. The obvious choice to be used with nandrolone decanoate is
testosterone enanthate or cypionate due to the length of the esters being
similar. How much testosterone one would need to take to ward off side effect
associated with use of nandrolone and lack of natural testosterone production
varies from individual to individual. Some have anecdotally reported that a
low dose similar to 200mgs per week is enough. Others state that they need to
run several hundreds more milligrams per week of testosterone than nandrolone
to combat the effects. There is a small minority of individuals that also
report having no sexual dysfunction from the drug even while running it
without any type of testosterone. This variance again demonstrates that
individuals will react to a compound differently than others.
This effect also points to the fact that nandrolone is extremely suppressive
to a user's natural testosterone production. Even at relatively small doses,
much smaller than those that would be used by those wanting to reap the
anabolic effects that the compound can offer, nandrolone can suppress the
natural production of testosterone of a user so much that it can take up to
thirty days after the drug cycle is complete for it to fully recover (2). For
this reason it is imperative that a user run a well planned post cycle therapy
after using nandrolone.
Nandrolone is relatively safe in terms of a user's lipid profile and
cholesterol. In some studies it has even been shown to actually improve HDL
cholesterol levels (4). A major increase in a user's blood pressure or their
liver toxicity should not be noticed with this compound either. Nandrolone is
relatively mild in these respects.
Since nandrolone is a progestinic anabolic steroid (3,4). Some special
precautions need to be taken to ensure that side effects do not get out of
control as a result of a rise in prolactin levels. Using compounds such as
bromocriptine, cabergoline and/or vitamin b6 have all been shown and reported
to help lower prolactin levels. The drug Femara (letrozole) is also effective
for use with nandrolone as it will regulate the progesterone and estrogen
receptors in the body, therefore preventing some of the negative side effects
associated with the compound.
A word of caution also for those that may plan on stacking nandrolone with
trenbolone. Trenbolone is a strong progestin, much stronger than even
nandrolone. By running these two compounds concurrently the user will suffer
from extremely high levels of prolactin. This in turn will force the user to
pay special attention to progesterone-like side effects and using compounds to
prevent them, as well as having to run a particularly aggressive post-cycle
therapy due to severe suppression of the hypothalamus pituitary testicular
axis. Some users have anecdotally reported that they have suffered no ill
effects of running the two compounds together, but it is a definite risk. One
must weigh the costs versus the benefits.
References
1. Sundaram K, Kumar N, Monder C, Bardin CW., Different
patterns of metabolism determine the relative anabolic activity of
19-norandrogens., J Steroid Biochem Mol Biol. 1995 Jun;53(1-6):253-7
2. Spitz IM, Margalioth EJ, Yeger Y, Livshin Y, Zylber-Haran E, Shilo S.
Effect of non aromatizable androgens on LHRH and TRH responses in primary
testicular failure. Horm Metab Res. 1984 Sep;16(9):492-7.
3 Hochberg RB, Hoyte RM, Rosner W., E-17
alpha-(2-[125I]iodovinyl)-19-nortestosterone: the synthesis of a
gamma-emitting ligand for the progesterone receptor., Endocrinology 1985
Dec;117(6):2550-2
4.Sattler FR, Schroeder ET, Dube MP, Jaque SV, Martinez C, Blanche PJ, Azen S,
Krauss RM. Metabolic effects of nandrolone decanoate and resistance training
in men with HIV. Am J Physiol Endocrinol Metab. 2002 Dec;283(6): E1214-22
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