Methandriol Methylandrostenediol
Methandriol Methylandrostenediol
Pharmaceutical Name: Methylandrostenediol
Chemical structure: 17a-Methyl-5-androstene-3B,17B-diol
Chemical Formula: C20 H32 O2
Molecular Weight: 304.4716
Chemical Formula: C20 H32 O2
Active life: less then 24 hours via intra-muscular injection
Anabolic/Androgenic ratio: 30-60/20-60
Methylandrostenediol is an anabolic steroid that gained popularity because of
its reputation for putting on significant body mass to meat producing animals,
with these results attempting to be reproduced by steroid users. The steroid
utilizes 17 alpha alkylation as to better prepare the compound to resist being
broken down by the liver when ingested orally. As stated, it is still primarily
manufactured for use in veterinary medicine as a means to help increase weight
gain in meat producing animals and was first marketed in the 1980s. For strength
athletes and bodybuilders it is thought to produce weight gain in users when
used in adequate doses, although these gains often result in both increases in
muscle as well as water retention and body fat due to the unique characteristics
of the compound.
Methylandrostenediol is simply the drug 5-androstenediol that has under gone 17
alpha alkylation so as to prevent, or at the very least reduce, breakdown in the
liver. For the most part methylandrostenediol possesses extremely mild abilities
to produce great gains in muscle size and/or strength. Obviously this is due to
its low anabolic and androgenic properties. While it is likely that some
muscular size and strength increases will be noted by the user, these will
likely be far less then most other popular anabolic steroids. Even the gains
that are made may be produced via different mechanisms however. For example, the
additional water retention and body weight increase that a user of
methylandrostenediol is likely to experience may just be as likely a cause of
any increased strength as the low androgenic response produced by the compound
would likely achieve. The same may also be true of the increase body weight that
a user would put on during a cycle of the drug.
The reputation that methylandrostenediol gained amongst cattle, pig and other
meat producing animal producers for these increases in body weight of their
livestock may have been enhanced beyond its practical application for a number
of reasons. Firstly, methylandrostenediol is rarely used alone in veterinary
medicine. It is most often combined with other compounds, trenbolone being one,
to produce the desired results. This combination of a major anabolic
(trenbolone) with a mild anabolic with estrogenic properties
(methylandrostenediol) would lead to major increases in both overall body weight
as well as muscle mass in the treated animals. However while steroid users may
be tempted to run such drug combinations themselves in an attempt to duplicate
such results, as will be outlined below, the side effects associated with
methylandrostenediol will likely make this practice impossible for most users.
So having noted these limitations of the drug, the major benefit of
methylandrostenediol is its ability to inhibit the muscle wasting effects of
glucocorticoid hormones (1). This muscle-sparing effect would obviously be
beneficial to the user but its effects would not be overly dramatic. Some
improvement in immune function could also be noted (2), but again this will
likely be slight in the overall picture for the steroid user.
Use and Dosing of Methylandrostenediol
Due to the fact that methylandrostenediol is a 17 alpha alkylated steroid, it
can be administered via intra-muscular injection or orally. The compound is an
ester-less suspension in most cases, although some users may be able to find
some tabs of the compound available. An esterified form of the compound,
methylandrostenediol dipropionate, is also available in an injectable form. This
allows for an extended active life. However this ester still is rather short so
frequent doses would still be necessary. In its oral form its active life is
still also relatively small so oral doses should take place at least once or
twice daily to maintain blood levels of the drug in the system of the user,
while injections of the esterless compound should also take place daily for the
most beneficial results.
Recommended doses administered by users range from as low as 10 milligrams per
day for women to 60 milligrams per day for first time male users. Of course like
all drugs, many users will use dosages that exceed these limits with the risks
of experiencing negative side effects increasing with these dosages.
It can be concluded that the best use for methylandrostenediol is short-term
with most users preferring to use the product for between four to six weeks,
although some will prolong the use with limited consequences to health, despite
its strong hepatoxic effects. One would also want to be extremely hesitant to
combine this compound with other 17 alpha alkylated steroids that are likely to
add additional stress to liver function.
Due to the characteristics of the compound, users are most likely to stack
methylandrostenediol with other compounds. Testosterone is an obvious choice due
to the estrogenic side effects that can result from its use, i.e. diminished sex
drive. However because of these estrogenic side effects users will also want to
take precautions when choosing other compounds to run along with it that they do
not create new problems or exacerbate the ones already brought on by
methylandrostenediol. For example, a user may want to avoid a compound such as
methandrostenolone which often results in a great deal of water retention due to
the effect that methylandrostenediol has on a user�s blood pressure and the
bloat that it also produces in many users.
Risks and Side Effects while using Methylandrostenediol
Methylandrostenediol is a 17 alpha alkylated compound and includes the usual
associated risks and stresses that those compounds place on the liver. Seemingly
as long as extremely high doses of the drug are not utilized by users no
significant damage should occur. With moderate dosing and cycle lengths
hepatoxicity should not be an issue for most healthy individuals.
For male users, the androgenic side effects should be minimal. Negative
androgenic responses to the drug such as hair loss, prostate difficulties, and
other problems should not occur in the vast majority of users. However
methylandrostenediol can cause of a myriad of problems in relation to the
estrogenic side effects it is capable of producing. 5-androstenediol itself acts
upon the estrogen receptor and therefore can help to produce estrogenic side
effects such as fat retention/gain, water retention and gynecomastia, among
others (3). This direct action upon the estrogen receptor poses a unique problem
for users as the use of aromatase inhibitors would for the most part be far less
useful in treating side effects related to this drug as the aromatize enzyme is
not a factor in creating these side effects. This potential lack of easily
combated estrogen-related side effects should be a major consideration when
users are debating on whether the costs outweigh the benefits of administering
this drug.
One unique aspect of methylandrostenediol is its effect on blood pressure. In
some cases it appears that the drug can lead to dramatic rises in blood pressure
is some users (4, 5). While this is not necessarily unique amongst most anabolic
steroids, the level to which the blood pressure of a user rises, the duration
that this rise lasts, and the amount of time it takes for it to normalize after
the administration of the drug is completed are quite different then most other
anabolic steroids. In one study it was demonstrated that in rats
methylandrostenediol caused a permanent rate of hypertension in some of the
treated animals (6). While no similar findings have been made in humans, this
information regarding the effect of the drug on blood pressure may be of some
concern for users that have pre-existing conditions and should of course be
noted when deciding whether to run this particular drug.
In terms of use of the drug by female athletes, due to the limited androgenic
nature of methylandrostenediol there is little likelihood of virilizing effects
in women. Of course this would be both cycle duration and dose dependent. As
well, in an animal study it appeared that the drug had no effect on the
reproductive ability of those female animals given the drug when the dosage was
kept to moderate levels. However, even when given relatively large doses, any
inhibition of reproductive ability dissipated within one month of cessation of
the drug (7). No data exists using human subjects in this related area of
research.
References
1. Salehian, B. and Kejriwal, K. Glucocorticoid-induced muscle
atrophy: mechanisms and therapeutic strategies. Endocr Pract. 1999; 5(5):277-81.
Androstenediol stimulates myelopoiesis and enhances resistance to infection in
gamma-irradiated mice. Int J Immunopharmacol. 2000 Jan;22(1):1-14.
2. Whitnall MH, Elliott TB, Harding RA, Inal CE, Landauer MR, Wilhelmsen CL,
McKinney L, Miner VL, Jackson WE3rd, Loria RM, Ledney GD, Seed TM.
3. Purohit A, Woo LW, Chander SK, Newman SP, Ireson C, Ho Y, Grasso A, Leese MP,
Potter BV, Reed MJ. Steroid sulphatase inhibitors for breast cancer therapy. J
Steroid Biochem Mol Biol. 2003 Sep;86(3-5):423-32.
4. McCall AL, Stern J, Dale SL, Melby JC. Adrenal steroidogenesis in
methylandrostenediol-induced hypertension. Endocrinology. 1978 Jul;103(1):1-5.
5. Molteni A, Colby HD, Skelton FR, Brownie AC. Prevention of
methylandrostenediol, methyltestosterone and testosterone-induced hypertension
in the rat by hypophysectomy. Proc Soc Exp Biol Med. 1972 Dec;141(3):936-9.
6. Molteni A, Brownie AC, Nickerson PA, Skelton FR. Irreversibility of
methylandrostenediol-induced hypertension in the rat after suspension of the
androgen treatment. Am J Pathol. 1972 Oct;69(1):179-94.
7. Turner JE, Irvine CH. Effect of prolonged administration of anabolic and
androgenic steroids on reproductive function in the mare. J Reprod Fertil Suppl.
1982;32:213-8.
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