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T-3 all you need to know
by BigAndy69
Introduction: What is T3?
Cytomel is a thyroid hormone that speeds up the metabolism causing a faster conversion of carbohydrates, proteins and fats.
The result is increased fat burning. This drug is usually used as a part of cut (dieting) cycles. Stack of Cytomel and Clenbuterol
is probably the best fat burning stack , Cytomel is also very popular with women. Start with one or half a tablet and slowly increase
the dose over next few days until you reach the required dose. Liothyronine sodium is to be taken divided throughout the day and the
cycles should be kept short ( 4-6 weeks) with an off period of at least 4 - 6 weeks.
What about T4?
Bodybuilders should not use T4. It???s a much weaker drug designed for long term
use in patients with chronic thyroid disease. 100mcg of T4 corresponds to 25mcg
of T3 and offers equivalent thyroid support; however, this does not translate to
equal weight loss benefits. It has made itself on sources??? lists simply
because it is widely available and extremely cheap.
Is T3 catabolic?
It may shock many people to know that T3 is NOT catabolic per se. Cortical
steroids are catabolic drugs that attack muscle tissue directly regardless of
caloric intake; T3 does not. It is a very potent calorie burner and it does not
discriminate between carbohydrates, protein and fat. Unlike DNP, it has no
protein sparing properties. T3 is also more likely to burn muscle than fat in
lean users (10-12% BF), but this can be said for any extreme drop in caloric
intake and uptake such as starvation diets (Caloric intake <10 X BW).
Muscle loss can be avoided with the use of anabolic agents. T3???s alleged
catabolic properties have become legendary. Excessive amounts of T3 (more than
75mcg), will have a very strong calorie burning effect, and since some
bodybuilder use 150 mcg, it???s easy to see why such misinformation has been so
prevalent. The average bodybuilder will not need several grams of steroids to
counter a reasonable dose of T3. There is no need to use more than 75mcg-100mcg.
Going beyond this dose will cause more harm than good, as massive doses of
steroids need to be used to counter the muscle loss, further stressing the body
for minimal, if any additional benefits.
I think I???ve lost 20 lbs of muscle!
T3 can also give your muscles an extremely flat look and very soft feel. This
side effect of extreme glycogen depletion can have a very profound psychological
impact in bodybuilders. It often feels and looks like muscle loss when it???s
simply a lack of muscle ???pump??? because of restricted blood flow to that area
and depletion of glycogen stores in muscles. Generally, carbohydrate loading
does not solve this problem. ???Pumping up??? (or training for that matter)
brings more blood into the muscles and is a temporary albeit effective solution.
Clenbuterol and certain steroids can offset the lack of muscle pump because
these drugs tend to ???harden up??? users by bringing more blood into to the
muscles.
Are steroids absolutely necessary on T3?
This is very dependent on the user. Diet must be flawless, only reasonable doses
should be considered (50mcg) and the user must know his body to a tee. Those who
don???t know what that last statement entails should not even consider T3. This
is a veteran drug and should not be used by bodybuilders who are new to the game
or do not have a deep understanding of how there bodies react to certain foods
and training philosophies.
T3 can be used alone or better yet with Clenbuterol without fear of muscle loss
in overly fat people (20-25% BF). This is not recommended, however, since these
people will generally return to overeating upon discontinuation of their cycle
and may likely end up with more weight than they started with.
How should I eat on T3?
Protein should be kept at 1.5-2g per lb of bodyweight. The majority of protein
should come from lean meats. Shakes can be used, but should not be heavily
relied on as they are more likely to be turned into glucose and used immediately
for energy. Caloric reduction should come from carbs and fat only.
What
is T3 used for?
Fat-loss:
The main use for T3.
Increase Nutrient Uptake: Not very well known, but this is a great use for T3.
Doses between 6.25-12.5mcg do not shutdown endogenous thyroid output. T3 at this
dose can be used to add LBM and help in keeping the fat off. When doses are kept
at 6.25-12.5mcg, muscles are full and rock hard, and energy is through the roof.
At these light doses, it???s common for people to go to the bathroom 5-6 times a
day because there bodies are making more efficient use of the food they eat.
Can I permanently shutdown my Thyroid?
Simply put, NO, it can???t happen. Natural thyroid production will be completely
shutdown for a good period of time after using T3, but it will eventually
recover. Bruce Kneller posted this study on the Testosterone website:
N Engl J Med 1975 Oct 2;293(14):681-4
Recovery of pituitary thyrotropic function after withdrawal of prolonged
thyroid-suppression therapy.
Vagenakis AG, Braverman LE, Azizi F, Portinay GI, Ingbar SH.
The pattern of thyrotropin secretion was analyzed in seven euthyroid women,
before and after withdrawal of long-term thyroid hormone, by serial measurements
of thyroid 131l uptake, serum thyroxine, tri-iodothyronine, and thyrotropin
concentrations, and the response to thyrotropin-releasing hormone. During
exogenous hormone administration, 131l uptake was suppressed, and serum
thyrotropin concentrations before and after administration of thyrotropin-releasing
hormone were undetectable.
After withdrawal of exogenous hormone, thyrotropin secretory function was
transiently impaired, as indicated by undetectable basal thyrotropin
concentrations together with absence of response to thyrotropin-releasing
hormone, and subsequently by normal values of basal thyrotropin concentration
and normal responses to releasing hormone while serum thyroxine and tri-iodothyronine
concentrations were subnormal.
Decreased thyrotropin reserve persisted for two to five weeks. Detectable values
of serum thyrotropin (less than 1.2 muU per milliliter) and a normal 131l uptake
usually occurred concurrently in two to three weeks. Serum thyroxine
concentration returned to normal at least four weeks after hormone withdrawal.
Basically, it is extremely important to eat cleanly and keep up with cardio for
at least 4 weeks and up to 6 weeks following a T3 cycle. It???s also very
important to ramp down properly and not use any drug that have an effect on
metabolism and thyroid function, i.e. Clen, Ephedrine, Steroids, DNP, T2???
Calories should be kept in check, even lowered in some cases, and High Intensity
Cardio is a must; at least 20mins, 3times a week. L-Tyrosine can be used at 1-3g
a day to help thyroid function, but its effectiveness is debatable.
Switching to a higher carb, lower fat and lower protein diet is crucial in
helping your thyroid bounce back after a cycle. A three-day carb up would be a
good idea following a T3 cycle. This study demonstrates how important
carbohydrates are for normal thyroid function. (Note: Some people seem to think
of carbs as Lucky Charms and toast when there are far better carb choices that
won???t make you look like the Michelin Man.)
Dietary-induced alterations in thyroid hormone metabolism during overnutrition.
Danforth E Jr, Horton ES, O'Connell M, Sims EA, Burger AG, Ingbar SH, Braverman
L, Vagenakis AG.
Diet-induced alterations in thyroid hormone concentrations have been found in
studies of long-term (7 mo) overfeeding in man (the Vermont Study). In these
studies of weight gain in normal weight volunteers, increased calories were
required to maintain weight after gain over and above that predicted from their
increased size. This was associated with increased concentrations of
triiodothyronine (T3). No change in the caloric requirement to maintain weight
or concentrations of T3 was found after long-term (3 mo) fat overfeeding. In
studies of short-term overfeeding (3 wk) the serum concentrations of T3 and its
metabolic clearance were increased, resulting in a marked increase in the
production rate of T3 irrespective of the composition of the diet overfed
(carbohydrate 29.6 +/- 2.1 to 54.0 +/- 3.3, fat 28.2 +/- 3.7 to 49.1 +/- 3.4,
and protein 31.2 +/- 2.1 to 53.2 +/- 3.7 microgram/d per 70 kg). Thyroxine
production was unaltered by overfeeding (93.7 +/- 6.5 vs. 89.2 +/- 4.9
microgram/d per 70 kg). It is still speculative whether these dietary-induced
alterations in thyroid hormone metabolism are responsible for the simultaneously
increased expenditure of energy in these subjects and therefore might represent
an important physiological adaptation in times of caloric affluence. During the
weight-maintenance phases of the long-term overfeeding studies, concentrations
of T3 were increased when carbohydrate was isocalorically substituted for fat in
the diet. In short-term studies the peripheral concentrations of T3 and reverse
T3 found during fasting were mimicked in direction, if not in degree, with equal
or hypocaloric diets restricted in carbohydrate were fed. It is apparent from
these studies that the caloric content as well as the composition of the diet,
specifically, the carbohydrate content, can be important factors in regulating
the peripheral metabolism of thyroid hormones.
Part 2
A post cycle crash is inevitable; this is the time when your diet really
matters.
So how do I cycle this stuff?
T3/Clen/Anavar Cycle
Anavar is the single best steroid to stack with T3. Its anti-catabolic
properties are unmatched and it will not shut down the HPTA. There???s nothing
like simultaneous sex hormone and thyroid hormone shutdown, I bet it feels
great. Primobolan at 200mg a week would be a good substitute since it doesn???t
shut you down. Dbol at 10-15mg taken in the morning can also be used but
Arimidex must be included with the Dbol. T3 increases the amount of
beta-3-adregenic receptors (by 500%!) in white adipose tissue, i.e. the fat that
covers muscle. Since clen exerts most of its effect on the same receptors, the
combination with T3 would yield quite a strong synergistic effect. T3/Clen may
be too much for the heart in some people.
T3:
12.5mcg for 5-7 days (optional but recommended)
37.5mcg for 5 days
75mcg for 15 days
50mcg for 5 days
37.5mcg for 5 days
25mcg for 5 days
12.5 mcg for 5 days
6.25mcg for 5-7 days
Clen:
30 days: 60-120mcg ED. Use clen from the first 37.5mcg dose to the last 25mcg
dose. Ketotifen will make you more sensitive to clenbuterol so doses should be
adjust accordingly.
Ketotifen:
Stacked with Clenbuterol, 2mg ED. This drug may not be an option for some people
since it can make them extremely hungry. If this is the case, Clen should be
used 2 weeks on 2 weeks off.
Anavar:
Oxandrin;
15mg ED with 37.5mcg of T3,
25mg ED with 75mcg of T3,
20mg ED with 50mcg of T3.
Here???s a more sensitive approach that can be used between cycles since it
doesn???t include AS:
BigAndy69???s
T3 Cycle:
The cycle can actually be used to add muscle mass or drop body fat depending on
caloric intake. For gaining muscle mass, the Yohimbine and Anastrozole are not
necessary.
W1-W4:
T3: 12.5mg ED
Clen: 60-100mcg ED
Ketotifen: 2mg ED
Anastrozole: 0.5mg ED
Yohimbe: 10-15mg ED (maybe too much to handle in some)
Carb/Pro/Fat:
20-30/50-60/20
ALA: 1500mg ED
Taurine: 3g ED
W5:
T3: 6.25mg ED
L-Tyrosine: 1-2g ED
ALA: 2500mg ED
Taurine: 3g ED
Carb/Pro/Fat:
50-60/20-30/20
(High Intensity Cardio)
W6:
ALA: 1500mg ED
Carb/Pro/Fat:
40/40/20
(High Intensity Cardio)
BigAndy69???s
T3 Post Cycle Therapy (4-6 weeks):
Initial 3 day carb up:
Carbs: 1.75g X BW
Protein: 0.75g X BW
Fat: 0.25g X BW
Supplements:
L-Tyrosine: 1-3g ED
ALA: 1500mg ED
Flaxseed oil + Fish oil: 20g total ED
Diet: >50% Carbs/ 30% Protein/ <20% Fat, calories at maintenance (+ or -
12 X BW)
High intensity cardio: 75-80% of Max Heart Rate; 15-20 min 3-4 times a week.
No Steroids, Ephedrine, Clen, T2, DNP, or anything that has an effect on
metabolism. Moderate doses of caffeine can be used before cardio.
BigAndy69
Disclaimer
T3 is not a drug that should be taken lightly. It???s a very potent thyroid
hormone. Messing with your natural hormone levels is very dangerous and
unpredictable. The potential for complications is very high, and abuse can lead
to thyroid disease and low thyroid output not only immediately upon
discontinuation, but also later in life.
There is no such thing as safe use of T3 outside of a medical setting. There is
only ???safer??? use. Use at your own risk.
Metabolism 1981 Aug;30(8):783-91
Whole body leucine and lysine metabolism studied with [1-13C]leucine and
[alpha-15N]lysine: response in healthy young men given excess energy intake.
Motil KJ, Bier DM, Matthews DE, Burke JF, Young VR.
Dietary-induced alterations in thyroid hormone metabolism during overnutrition.
Danforth E Jr, Horton ES, O'Connell M, Sims EA, Burger AG, Ingbar SH, Braverman
L, Vagenakis AG.
Rubio A, et al. "Thyroid hormone and norepinephrine signaling in brown
adipose tissue. II: Differential effects of thyroid hormone on beta 3-adrenergic
receptors in brown and white adipose tissue." Endocrinology 1995
Aug;136(8):3277-84
A paradigm of experimentally induced mild hyperthyroidism: effects on nitrogen
balance, body composition, and energy expenditure in healthy young men.
J Clin Endocrinol Metab 1997 Mar;82(3):765-70 (ISSN: 0021-972X)
Lovejoy JC; Smith SR; Bray GA; De Lany JP; Rood JC; Gouvier D; Windhauser M;
Ryan DH; Macchiavelli R; Tulley R
Pennington Biomedical Research Center, Louisiana State University, Baton Rouge
70808, USA. lovejoj@mhs.pbrc.edu
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